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Publié le 14/12/2018
SOLEIL's contribution to Medical Diagnosis and Prognosis
In close collaboration with hospitals, SOLEIL takes part in the design of new methods to diagnose diseases at an early stage and seeks to better understand the evolution of pathologies. Its longterm...
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Publié le 18/10/2018
Innovative anticancer drugs: Discovery of new inhibitors for MDM2, involved in cell...
The immortality of cancer cells associated with loss of life/death control mechanisms such as the regulation of apoptosis (programmed cell death), is a common stage in tumours. Mitochondria play an...
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Publié le 05/10/2018
Radiotherapy: repair proteins in search of the ring to protect DNA
To understand why some cancer cells resist radiotherapy, an international team of researchers has used crystallography to “photograph” the first moments of the molecular ballet that allows these...
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Publié le 18/04/2018
Structural basis of vesicular stomatitis virus entry into host cells
Vesicular stomatitis virus (VSV) is an enveloped virus which can infect insects, cattle, horses, and pigs. In mammals, its ability to infect and kill tumor cells, although sparing normal cells, makes...
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Publié le 30/03/2017
Promising anti-malarial compounds revealed thanks to the understanding of human protein...
In order to deal with the recent decline in the effectiveness of antimalarial treatments, new therapeutic solutions are currently being explored to fight against malaria. Researchers from University...
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Publié le 16/03/2017
Fusion between male and female sex cells has an equivalent in viruses
The 3D structure of the HAP2 protein, involved in this process in a unicellular alga, was solved using crystallization and X-ray diffraction. It appeared to be homologous to viral fusion proteins....
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Publié le 26/01/2017
10 years of collaboration SOLEIL/INRA
It is now 10 years since INRA and SOLEIL have engaged a fruitful collaboration, which relies on the presence of INRA who work on secondment on SOLEIL beamlines. A booklet, published in January...
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Publié le 25/01/2017
RNA splicing - the lariat conformation captured at PROXIMA-1!
Group II introns are large catalytic RNAs and mobile genetic elements of bacterial origin. They are considered to be the ancestors of nuclear introns in eukaryotes and their splicing machinery, the...
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Publié le 07/12/2016
The crystallographic structure of the enzyme PolD suggests a new paradigm for...
In all forms of cellular life, the enzymes DNA polymerases (DNAPs) play a central role in the replication, maintenance and repair of the genome. Consequently, the DNAPs have been the subject of...
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