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Development of Thioaryl-based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR and Crystallographic Studies
Publié le 15/05/2018
... Nuti, E., Cuffaro, D., Bernardini, E., Camodeca, C., Panelli, L., Chaves, S., Ciccone, L., Tepshi, L., Vera, L., Orlandini, E., Nencetti, S., Stura, E.A., Santos, M.A., Dive, V., Rossello, A. "Development of Thioaryl-based Matrix Metalloproteinase-12 ...
Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels
Publié le 27/04/2018
... Fourati, Z., Howard, R.J., Heusser, S.A., Hu, H., Ruza, R.R., Sauguet, L., Lindahl, E., Delarue, M. "Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels" Cell Reports., 23(4): 993 ...
Des membranes des Archées à l’industrie : la clé de la réaction de biosynthèse du mévalonate révélée
Publié le 10/04/2018
... Des chercheurs de l´institut Max Planck pour la microbiologie terrestre (Marburg, Allemagne), de l’Institut de Biologie Structurale (Grenoble) et de l´ENS (Lyon) ont déterminé la structure du complexe d’enzymes responsable de la synthèse du ...
Attraction de longue portée entre surfaces hydrophobes - Mesure directe des corrélations latérales sous nano-confinement contrôlé
Publié le 10/04/2018
... Alors que l’effet hydrophobe est à la base de nombreux phénomènes chimiques ou biologiques, l’interaction entre deux substrats hydrophobes restait incomprise. Grâce à la mise au point d’un dispositif expérimental ultra-sensible couplant les ...
Lytic xylan oxidases from wood-decay fungi unlock biomass degradation
Publié le 10/04/2018
... Couturier, M., Ladevèze, S., Sulzenbacher, G., Ciano, L., Fanuel, M., Moreau, C., Villares, A., Cathala, B., Chaspoul, F., Frandsen, K.E., Labourel, A., Herpoël-Gimbert, I., Grisel, S., Haon, M., Lenfant, N., Rogniaux, H., Ropartz, D., Davies, G.J., Rosso ...
Recent developments in MrBUMP: better search-model preparation, graphical interaction with search models, and solution improvement and assessment
Publié le 07/04/2018
... Keegan, R.M., McNicholas, S.J., Thomas, J.M.H., Simpkin, A.J., Simkovic, F., Uski, V., Ballard, C.C., Winn, M.D., Wilsond, K.S., Rigden, D.J. "Recent developments in MrBUMP: better search-model preparation, graphical interaction with search models, and ...
The plant defense signal galactinol is specifically used as a nutrient by the bacterial pathogen Agrobacterium fabrum
Publié le 04/04/2018
... Meyer, T., Vigouroux, A., Aumont-Nicaise, M., Comte, G., Vial, L., Lavire, C., Morera, S. "The plant defense signal galactinol is specifically used as a nutrient by the bacterial pathogen Agrobacterium fabrum" Journal of Biological Chemistry., 293(21): ...
Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease
Publié le 27/03/2018
... Gaspar, L., Coron, R.P., KongThoo Lin, P., Costa, D.M., Perez-Cabezas, B., Tavares, J., Roura-Ferrer, M., Ramos, I., Ronin, C., Major, L.L., Ciesielski, F., Pemberton, I.K., MacDougall, J., Ciapetti, P., Smith, T.K., Cordeiro-da-Silva, A. "Inhibitors of ...
Proteome-level assessment of origin, prevalence and function of Leucine-Aspartic Acid (LD) motifs
Publié le 20/03/2018
... Alam, T., Alazmi, M., Naser, R., Huser, F., Momin, A.A., Walkiewicz, K.W., Canlas, C.G., Huser, R.G., Ali, A., Merzaban, J., Bajic, V.B., Gao, X., Arold, S.T. "Proteome-level assessment of origin, prevalence and function of Leucine-Aspartic Acid (LD) ...
Direct Measurement of Lateral Correlations under Controlled Nanoconfinement
Publié le 17/03/2018
... Kékicheff, P., Iss, J., Fontaine, P., Johner, A. "Direct Measurement of Lateral Correlations under Controlled Nanoconfinement" Physical Review Letters., 120(11): art.n° 118001. (2018). ...