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The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution
Publié le 18/09/2024
... Chazot, A., Zimberger, C., Feracci, M., Moussa, A., Good, S., Sommadossi, J.P., Alvarez, K., Ferron, F., Canard, B. "The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution" PloS Biology., 22(8): art.n° ...
Comment le Coronavirus HKU1 force la porte d’entrée de nos cellules
Publié le 23/08/2024
... Des scientifiques de l’Institut Pasteur ont mis à jour les endroits précis des cellules respiratoires où se fixe le coronavirus HKU1, permettant ainsi d’expliquer en détail le mécanisme d’infection mis en œuvre. Une découverte qui a permis d ...
Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody
Publié le 23/08/2024
... Pinto Torres, J.E., Claes, M., Hendrickx, R., Yuan, M., Smiejkowska, N., Van Wielendaele, P., De Winter, H., Muyldermans, S., Michels, P.A., Walkinshaw, M.D., Versées, W., Caljon, G., Magez, S., Sterckx, Y.G.J. "Allosteric inhibition of trypanosomatid ...
Bioinformatic, Enzymatic, and Structural Characterization of Trichuris suis Hexosaminidase HEX-2
Publié le 29/07/2024
... Dutkiewicz, Z., Varrot, A., Breese, K.J., Stubbs, K.A., Nuschy, L., Adduci, I., Paschinger, K., Wilson, I.B.H. "Bioinformatic, Enzymatic, and Structural Characterization of Trichuris suis Hexosaminidase HEX-2" Biochemistry., 53(15): 1941-1954. (2024). ...
Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy
Publié le 24/07/2024
... Hartman, J.J., Hwee, D.T., Robert-Paganin, J., Chuang, C., Chin, E.R., Edell, S., Lee, K.H., Madhvani, R., Paliwal, P., Pernier, J., Sarkar, S.S., Schaletzky, J., Schauer, K., Taheri, K.D., Wang, J., Wehri, E., Wu, Y., Houdusse, A., Morgan, B.P., Malik, F ...
Allosteric nanobodies to study the interactions between SOS1 and RAS
Publié le 24/07/2024
... Fischer, B., Uchański,T., Sheryazdanova,A., Gonzalez,S., Volkov,A.N., Brosens,E., Zögg, T., Kalichuk, V., Ballet, S., Versées, W., Sablina, A.A., Pardon, E., Wohlkönig, A., Steyaert, J. "Allosteric nanobodies to study the interactions between SOS1 and RAS ...
Constrained Catalytic Itinerary of a Retaining 3,6-Anhydro-D-Galactosidase, a Key Enzyme in Red Algal Cell Wall Degradation
Publié le 19/07/2024
... Wallace, M.D., Cuxart, I., Roret, T., Guée, L., Debowski, A.W., Czjzek, M., Rovira, C., Stubbs, K.A., Ficko-Blean, E. "Constrained Catalytic Itinerary of a Retaining 3,6-Anhydro-D-Galactosidase, a Key Enzyme in Red Algal Cell Wall Degradation" Angewandte ...
Capturing Catalyst Strain Dynamics during Operando CO Oxidation
Publié le 16/07/2024
... Grimes, M., Atlan, C., Chatelier, C., Bellec, E., Olson, K., Simonne, D., Levi, M., Schülli, T.U., Leake, S.J., Rabkin, E., Eymery, J., Richard, M.I. "Capturing Catalyst Strain Dynamics during Operando CO Oxidation" ACS Nano., 18(30): 19608-19617 . (2024 ...
Dynamic BTB-domain filaments promote clustering of ZBTB proteins
Publié le 12/07/2024
... Mance, L., Bigot, N., Sánchez, E.Z., Coste, F., Martín-González, N., Zentout, S., Biliškov, M., Pukało, Z., Mishra, A., Chapuis, C., Arteni, A.A., Lateur, A., Goffinont, S., Gaudon, V., Talhaoui, I., Casuso, I., Beaufour, M., Garnier, N., Artzner, F., ...
Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus
Publié le 05/07/2024
... Fernández, I., Saunders, N., Duquerroy, S., Bolland, W.H., Arbabian, A., Baquero, E., Blanc, C., Lafaye, P., Haouz, A., Buchrieser, J., Schwartz, O., Rey, F.A. "Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal ...