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Résultats de la recherche ""
Molecular mechanism of IKK catalytic dimer docking to NF-κB substrates
Publié le 17/09/2024
... Li, C., Moro, S., Shostak, K., O’Reilly, F.J., Donzeau, M., Graziadei, A., McEwen, A.G., Desplancq, D., Poussin-Courmontagne, P., Bachelart, T., Fiskin, M., Berrodier, N., Pichard, S., Brillet, K., Orfanoudakis, G., Poterszman, A., Torbeev, V., Rappsilber ...
Comment le Coronavirus HKU1 force la porte d’entrée de nos cellules
Publié le 23/08/2024
... Des scientifiques de l’Institut Pasteur ont mis à jour les endroits précis des cellules respiratoires où se fixe le coronavirus HKU1, permettant ainsi d’expliquer en détail le mécanisme d’infection mis en œuvre. Une découverte qui a permis d ...
Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody
Publié le 23/08/2024
... Pinto Torres, J.E., Claes, M., Hendrickx, R., Yuan, M., Smiejkowska, N., Van Wielendaele, P., De Winter, H., Muyldermans, S., Michels, P.A., Walkinshaw, M.D., Versées, W., Caljon, G., Magez, S., Sterckx, Y.G.J. "Allosteric inhibition of trypanosomatid ...
Corynebacterium glutamicum pyruvate:quinone oxidoreductase: an enigmatic metabolic enzyme with unusual structural features
Publié le 01/08/2024
... da Silva Lameira, C., Münßinger, S., Yang, L., Eikmanns, B.J., Bellinzoni, M. "Corynebacterium glutamicum pyruvate:quinone oxidoreductase: an enigmatic metabolic enzyme with unusual structural features" FEBS Journal., 290(20): 4501-4521. (2024). ...
Bioinformatic, Enzymatic, and Structural Characterization of Trichuris suis Hexosaminidase HEX-2
Publié le 29/07/2024
... Dutkiewicz, Z., Varrot, A., Breese, K.J., Stubbs, K.A., Nuschy, L., Adduci, I., Paschinger, K., Wilson, I.B.H. "Bioinformatic, Enzymatic, and Structural Characterization of Trichuris suis Hexosaminidase HEX-2" Biochemistry., 53(15): 1941-1954. (2024). ...
N-Acylbenzimidazoles as Selective Acylators of the Catalytic Cystein of the Coronavirus 3CL Protease
Publié le 26/07/2024
... Chaibi, F.Z., Brier, L., Carré, P., Landry, V., Desmarets, L., Tarricone, A., Cantrelle, F.X., Moschidi, D., Herledan, A., Biela, A., Bourgeois, F., Ribes, C., Ikherbane, S., Malessan, M., Dubuisson, J., Belouzard, S., Hanoulle, X., Leroux,, Deprez, B., ...
Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy
Publié le 24/07/2024
... Hartman, J.J., Hwee, D.T., Robert-Paganin, J., Chuang, C., Chin, E.R., Edell, S., Lee, K.H., Madhvani, R., Paliwal, P., Pernier, J., Sarkar, S.S., Schaletzky, J., Schauer, K., Taheri, K.D., Wang, J., Wehri, E., Wu, Y., Houdusse, A., Morgan, B.P., Malik, F ...
Allosteric nanobodies to study the interactions between SOS1 and RAS
Publié le 24/07/2024
... Fischer, B., Uchański,T., Sheryazdanova,A., Gonzalez,S., Volkov,A.N., Brosens,E., Zögg, T., Kalichuk, V., Ballet, S., Versées, W., Sablina, A.A., Pardon, E., Wohlkönig, A., Steyaert, J. "Allosteric nanobodies to study the interactions between SOS1 and RAS ...
Constrained Catalytic Itinerary of a Retaining 3,6-Anhydro-D-Galactosidase, a Key Enzyme in Red Algal Cell Wall Degradation
Publié le 19/07/2024
... Wallace, M.D., Cuxart, I., Roret, T., Guée, L., Debowski, A.W., Czjzek, M., Rovira, C., Stubbs, K.A., Ficko-Blean, E. "Constrained Catalytic Itinerary of a Retaining 3,6-Anhydro-D-Galactosidase, a Key Enzyme in Red Algal Cell Wall Degradation" Angewandte ...
Crystal structure of the class A extended-spectrum β-lactamase CTX-M-96 in complex with relebactam at 1.03 Angstrom resolution
Publié le 16/07/2024
... Ghiglione, B., Rodríguez, M.M., Penzotti, P., Bethel, C.R., Gutkind, G., Bonomo, R.A., Klinke, S., Power, P. "Crystal structure of the class A extended-spectrum β-lactamase CTX-M-96 in complex with relebactam at 1.03 Angstrom resolution" Antimicrobial ...