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Des colles moléculaires pour assembler les protéines
Publié le 30/06/2017
... L'auto-assemblage de protéines en nanostructures ordonnées, comme les ossatures dynamiques qui donnent à différents types de cellules ou de virus leurs formes uniques, est une caractéristique de nombreux systèmes biologiques. Les ...
Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex
Publié le 28/06/2017
... Nguyen, V.S., Logger, L., Spinelli, S., Legrand, P., Pham, T.T.H., Trinh, T.T.N., Cherrak, Y., Zoued, A., Desmyter, A., Durand, E., Roussel, A., Kellenberger, C., Cascales, E., Cambillau, C. "Type VI secretion TssK baseplate protein exhibits structural ...
Exploiting sequence and stability information for directing nanobody stability engineering
Publié le 22/06/2017
... Kunz, P., Flock, T., Soler, N., Zaiss, M., Vincke, C., Sterckx, Y., Kastelic, D., Muyldermans, S., Hoheisel, J.D. "Exploiting sequence and stability information for directing nanobody stability engineering" Biochemica et Biophysica Acta (BBA) - General ...
Structural Snapshots and Loop Dynamics along the Catalytic Cycle of Glycosyltransferase GpgS
Publié le 17/06/2017
... Albesa-Jové, D., Romero-García, J., Sancho-Vaello, E., Contreras, F.X., Rodrigo-Unzueta, A., Comino, N., Carreras-González, A., Arrasate, P., Urresti, S., Biarnés, X., Planas, A., Guerin, M.E. "Structural Snapshots and Loop Dynamics along the Catalytic ...
Un piège complexe: nouvelles thérapeutiques potentielles contre l'asthme et les allergies communes, ciblant le récepteur TSLP humain
Publié le 06/06/2017
... La cytokine1 pro-inflammatoire TSLP (lymphopoïétine stromale thymique) joue un rôle essentiel dans les maladies allergiques largement répandues, notamment l'asthme et la dermatite atopique. Des données de diffraction des rayons X obtenues sur ...
Bacterial RadA is a DnaB-type helicase interacting with RecA to promote bidirectional D-loop extension
Publié le 02/06/2017
... Marie, L., Rapisarda, C., Morales, V., Bergé, M., Perry, T., Soulet, A.L., Gruget, C., Remaut, H., Fronzes, R., Polard, P. "Bacterial RadA is a DnaB-type helicase interacting with RecA to promote bidirectional D-loop extension" Nature Communications., 8: ...
Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase
Publié le 02/06/2017
... Mechaly, A.E., Soto Diaz, S., Sassoon, N., Buschiazzo, A., Betton, J.M., Alzari, P.M. "Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase" Structure., 25(6): 939–944.e3. (2017). ...
Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope
Publié le 02/06/2017
... Rouvinski, A., Dejnirattisai, W., Guardado-Calvo, P., Vaney, M.C., Sharma, A., Duquerroy, S., Supasa, P., Wiyada Wongwiwat, W., Haouz, A., Barba-Spaeth, G., Mongkolsapaya, J., Rey, F.A., Screaton, G.R. "Covalently linked dengue virus envelope glycoprotein ...
Structural and functional characterization of the hydrogenase-maturation HydF protein
Publié le 02/06/2017
... Caserta, G., Pecqueur, L., Adamska-Venkatesh, A., Papini, C., Roy, S., Artero, V., Atta, M., Reijerse, E., Lubitz, W., Fontecave, M. "Structural and functional characterization of the hydrogenase-maturation HydF protein" Nature Chemical Biology., 13(7): ...
Chemoproteomics-aided medicinal chemistry for the discovery of EPHA2 inhibitors
Publié le 02/06/2017
... Heinzlmeir, S., Lohse, J., Treiber, T., Kudlinzki, D., Linhard, V., Lakshmi Gande, S., Sreeramulu, S., Saxena, K., Liu, X., Wilhelm, M., Schwalbe, H., Kuster, B., Médard, G. "Chemoproteomics-aided medicinal chemistry for the discovery of EPHA2 inhibitors" ...