PROXIMA-1

Nitrate reduction salvage pathway in Methanococcales

Référence
A. Heidenreich, A. G. Gouveia, T. Wagner "Nitrate reduction salvage pathway in Methanococcales". Frontiers in Microbiology, 17():. (2026).
Année de publication
2026
Auteurs
A. Heidenreich
A. G. Gouveia
T. Wagner
Lignes de lumière
rec-number
13345
Référence anonyme
A. Heidenreich, A. G. Gouveia, T. Wagner "Nitrate reduction salvage pathway in Methanococcales". Frontiers in Microbiology, 17():. (2026).
Type de publication
Date

Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta

Référence
J. Sheng, K. Frausto, S. Haesaerts, T. J. Meyer, M. Prolič-Kalinšek, S. E. O'Leary, R. Loris, P. B. Larsen "Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta". Plant, Cell & Environment, online first (14/07/2026)():. (2026).
Année de publication
2026
Auteurs
J. Sheng
K. Frausto
S. Haesaerts
T. J. Meyer
M. Prolič-Kalinšek
S. E. O'Leary
R. Loris
P. B. Larsen
Lignes de lumière
rec-number
13330
Référence anonyme
J. Sheng, K. Frausto, S. Haesaerts, T. J. Meyer, M. Prolič-Kalinšek, S. E. O'Leary, R. Loris, P. B. Larsen "Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta". Plant, Cell & Environment, online first (14/07/2026)():. (2026).
Type de publication
Date

Rational Design of Diaryl Ether-Based Dual Inhibitors Targeting Successive Essential Enzymes HadAB and InhA in Mycobacterium tuberculosis

Référence
R. Tamhaev, D. Recchia, M. Záhorszká, G. Stelitano, L. Robert Chiarelli, J. Rizet, J. Rima, M. Chebaiki, L. Valentin, J. Azéma-Despeyroux, P. Hoffmann, N. Preuilh, B. Dumais, S. Britton, G. Degiacomi, L.Maveyraud, J. Korduláková, M. Rosalia Pasca, L. Mourey, C. Lherbet "Rational Design of Diaryl Ether-Based Dual Inhibitors Targeting Successive Essential Enzymes HadAB and InhA in Mycobacterium tuberculosis". Journal of Medicinal Chemistry, online first (07/07/2026)():. (2026).
Année de publication
2026
Auteurs
R. Tamhaev
D. Recchia
M. Záhorszká
G. Stelitano
L. Robert Chiarelli
J. Rizet
J. Rima
M. Chebaiki
L. Valentin
J. Azéma-Despeyroux
P. Hoffmann
N. Preuilh
B. Dumais
S. Britton
G. Degiacomi
L.Maveyraud
J. Korduláková
M. Rosalia Pasca
L. Mourey
C. Lherbet
Lignes de lumière
rec-number
13309
Référence anonyme
R. Tamhaev, D. Recchia, M. Záhorszká, G. Stelitano, L. Robert Chiarelli, J. Rizet, J. Rima, M. Chebaiki, L. Valentin, J. Azéma-Despeyroux, P. Hoffmann, N. Preuilh, B. Dumais, S. Britton, G. Degiacomi, L.Maveyraud, J. Korduláková, M. Rosalia Pasca, L. Mourey, C. Lherbet "Rational Design of Diaryl Ether-Based Dual Inhibitors Targeting Successive Essential Enzymes HadAB and InhA in Mycobacterium tuberculosis". Journal of Medicinal Chemistry, online first (07/07/2026)():. (2026).
Type de publication
Date

Functional role of a tethered domain as a naturally fused cognate partner is demonstrated in a three-domain copper nitrite reductase

Référence
N. Petchyam, A. Mbouku, R. R. Eady, S. Samar Hasnaina, S. V. Antonyuka "Functional role of a tethered domain as a naturally fused cognate partner is demonstrated in a three-domain copper nitrite reductase". IUCrJ, 13(4):498-513. (2026).
Année de publication
2026
Auteurs
N. Petchyam
A. Mbouku
R. R. Eady
S. Samar Hasnaina
S. V. Antonyuka
Lignes de lumière
rec-number
13315
Référence anonyme
N. Petchyam, A. Mbouku, R. R. Eady, S. Samar Hasnaina, S. V. Antonyuka "Functional role of a tethered domain as a naturally fused cognate partner is demonstrated in a three-domain copper nitrite reductase". IUCrJ, 13(4):498-513. (2026).
Type de publication
Date

Structural basis of porcine reproductive and respiratory syndrome virus 2 neutralization by a GP4-targeting monoclonal antibody

Référence
B. Veselkova, C. Saikia, S. Affeldt, S. Barth, M. Kumar Rajak, F. Besa, D. Bezbakh, G. Hansen, T. Rümenapf, M. Ballmaier, O. Dittrich-Breiholz, H. Bamber, K. Nagarathinam, A. W. Tarr, B. Lamp, T. Krey "Structural basis of porcine reproductive and respiratory syndrome virus 2 neutralization by a GP4-targeting monoclonal antibody". Journal of General Virology, 107(6):. (2026).
Année de publication
2026
Auteurs
B. Veselkova
C. Saikia
S. Affeldt
S. Barth
M. Kumar Rajak
F. Besa
D. Bezbakh
G. Hansen
T. Rümenapf
M. Ballmaier
O. Dittrich-Breiholz
H. Bamber
K. Nagarathinam
A. W. Tarr
B. Lamp
T. Krey
Lignes de lumière
rec-number
13316
Référence anonyme
B. Veselkova, C. Saikia, S. Affeldt, S. Barth, M. Kumar Rajak, F. Besa, D. Bezbakh, G. Hansen, T. Rümenapf, M. Ballmaier, O. Dittrich-Breiholz, H. Bamber, K. Nagarathinam, A. W. Tarr, B. Lamp, T. Krey "Structural basis of porcine reproductive and respiratory syndrome virus 2 neutralization by a GP4-targeting monoclonal antibody". Journal of General Virology, 107(6):. (2026).
Type de publication
Date

Structural basis of HSP90C, a highly active chloroplastic HSP90 chaperone from Arabidopsis thaliana

Référence
R. La Rocca, T. Chenuel, C. Bergonzi, A. Maes, A. Pozza, P. Meyer "Structural basis of HSP90C, a highly active chloroplastic HSP90 chaperone from Arabidopsis thaliana". Journal of Molecular Biology, online first (06/07/2026)():. (2026).
Année de publication
2026
Auteurs
R. La Rocca
T. Chenuel
C. Bergonzi
A. Maes
A. Pozza
P. Meyer
Lignes de lumière
rec-number
13301
Référence anonyme
R. La Rocca, T. Chenuel, C. Bergonzi, A. Maes, A. Pozza, P. Meyer "Structural basis of HSP90C, a highly active chloroplastic HSP90 chaperone from Arabidopsis thaliana". Journal of Molecular Biology, online first (06/07/2026)():. (2026).
Type de publication
Date

Biochemical and structural characterization of a tail-spike protein with depolymerase activity identified in a marine podovirus

Référence
S. Sirigu, T. Roret, P.-Y. Mocaër, R. Larocque, D. Jouanneau, P. Legrand, A.-C. Baudouxc, M. Czjzek "Biochemical and structural characterization of a tail-spike protein with depolymerase activity identified in a marine podovirus". Acta Crystallographica D: Structural Biology, 82(7):785-799. (2026).
Année de publication
2026
Auteurs
S. Sirigu
T. Roret
P.-Y. Mocaër
R. Larocque
D. Jouanneau
P. Legrand
A.-C. Baudouxc
M. Czjzek
Lignes de lumière
rec-number
13269
Référence anonyme
S. Sirigu, T. Roret, P.-Y. Mocaër, R. Larocque, D. Jouanneau, P. Legrand, A.-C. Baudouxc, M. Czjzek "Biochemical and structural characterization of a tail-spike protein with depolymerase activity identified in a marine podovirus". Acta Crystallographica D: Structural Biology, 82(7):785-799. (2026).
Type de publication
Date

Structural dissection of the catalytic domain of the serine threonine kinase StkP of Streptococcus pneumoniae

Référence
M. Hamidi, V. Gueguen-Chaignon, C. Falcou, H. Millat, S. Narayanan Nagarajan, A. Le Roy, C. Freton, F. Gago, S. Ravaud, C. Grangeasse "Structural dissection of the catalytic domain of the serine threonine kinase StkP of Streptococcus pneumoniae". Nature Communications, online first (18/06/2026)():. (2026).
Année de publication
2026
Auteurs
M. Hamidi
V. Gueguen-Chaignon
C. Falcou
H. Millat
S. Narayanan Nagarajan
A. Le Roy
C. Freton
F. Gago
S. Ravaud
C. Grangeasse
Lignes de lumière
rec-number
13284
Référence anonyme
M. Hamidi, V. Gueguen-Chaignon, C. Falcou, H. Millat, S. Narayanan Nagarajan, A. Le Roy, C. Freton, F. Gago, S. Ravaud, C. Grangeasse "Structural dissection of the catalytic domain of the serine threonine kinase StkP of Streptococcus pneumoniae". Nature Communications, online first (18/06/2026)():. (2026).
Type de publication
Date

Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1

Référence
Otake, K., Ubukata, M., Nagahashi, N., Ogawa, N., Hantani, Y., Hantani, R., Adachi, T., Nomura, A., Yamaguchi, K., Maekawa, M., Mamada, H., Motomura, T. , Sato, M., Harada, K. "Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1−Nrf2 PPI Inhibitor". ACS Medicinal Chemistry Letters, 14(5):Array. (2023).
Année de publication
2023
Auteurs
Otake, K.
Ubukata, M.
Nagahashi, N.
Ogawa, N.
Hantani, Y.
Hantani, R.
Adachi, T.
Nomura, A.
Yamaguchi, K.
Maekawa, M.
Mamada, H.
Motomura, T.
Sato, M.
Harada, K.
Lignes de lumière
rec-number
12022
Référence anonyme
Otake, K., Ubukata, M., Nagahashi, N., Ogawa, N., Hantani, Y., Hantani, R., Adachi, T., Nomura, A., Yamaguchi, K., Maekawa, M., Mamada, H., Motomura, T. , Sato, M., Harada, K. "Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1−Nrf2 PPI Inhibitor". ACS Medicinal Chemistry Letters, 14(5):Array. (2023).
Type de publication
Date

Structure-Based Discovery of Potent BCL-XL Inhibitors through Rescaffolding

Référence
M. Pal Timari, A. Paczal, A. Herner, M. Molnar, Z. Madarasz, M. Nyerges, S. T. Bedford, T. Brooks, J. Davidson, Z. Daniels, M. Dodsworth, P. Dokurno, J. B. Murray, R. Parsons, E. Sanders, J. Smith, P. Webb, N. Whitehead, R. E. Hubbard, J.-B. Starck, A. L. Maragno, G. Le Toumelin-Braizat, L. Bresson, F. Rocchetti, D. Demarles, F. Colland, O. Geneste, A. Kotschy, T. Novak "Structure-Based Discovery of Potent BCL-XL Inhibitors through Rescaffolding". Journal of Medicinal Chemistry, online first (12/06/2026)():. (2026).
Année de publication
2026
Auteurs
M. Pal Timari
A. Paczal
A. Herner
M. Molnar
Z. Madarasz
M. Nyerges
S. T. Bedford
T. Brooks
J. Davidson
Z. Daniels
M. Dodsworth
P. Dokurno
J. B. Murray
R. Parsons
E. Sanders
J. Smith
P. Webb
N. Whitehead
R. E. Hubbard
J.-B. Starck
A. L. Maragno
G. Le Toumelin-Braizat
L. Bresson
F. Rocchetti
D. Demarles
F. Colland
O. Geneste
A. Kotschy
T. Novak
Lignes de lumière
rec-number
13261
Référence anonyme
M. Pal Timari, A. Paczal, A. Herner, M. Molnar, Z. Madarasz, M. Nyerges, S. T. Bedford, T. Brooks, J. Davidson, Z. Daniels, M. Dodsworth, P. Dokurno, J. B. Murray, R. Parsons, E. Sanders, J. Smith, P. Webb, N. Whitehead, R. E. Hubbard, J.-B. Starck, A. L. Maragno, G. Le Toumelin-Braizat, L. Bresson, F. Rocchetti, D. Demarles, F. Colland, O. Geneste, A. Kotschy, T. Novak "Structure-Based Discovery of Potent BCL-XL Inhibitors through Rescaffolding". Journal of Medicinal Chemistry, online first (12/06/2026)():. (2026).
Type de publication
Date