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Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors
Publié le 10/12/2024
... Palisse, A., Cheung, T., Blokhuis, A., Cogswell, T., Martins, B.S., Riemens, R., Schellekens, R., Battocchio, G., Jansen, C., Cottee, M.A., Ornell, K., Sacchetto, C., Leon, L., van Hoek-Emmelot, M., Bostock, M., Brauer, B.L., Beaumont, K., Lucas, S.C.C., ...
Enzymatic, structural, and biophysical characterization of a single-domain antibody (VHH) selectively and tightly inhibiting neutrophil elastase and exhibiting favorable developability properties
Publié le 04/12/2024
... Redeghieri, P., Moray, J., Kerff, F., Gohy S., Leal, T., Muyldermans, S., Vanbever, R., Morales-Yánez, F.J., Dumoulin, M. "Enzymatic, structural, and biophysical characterization of a single-domain antibody (VHH) selectively and tightly inhibiting ...
First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity
Publié le 04/12/2024
... Loureiro, J., Seoane, S., Sampaio-Dias, I.E., Peluso-Iltis, C., Guiberteau, T., Brito, B., Gregorio, C., Pérez-Fernández, R., Rochel, N., Mouriño, A., Rodríguez-Borges, J.E. "First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and ...
Thioredoxin 1 moonlights as a chaperone for an interbacterial ADP-ribosyltransferase toxin
Publié le 04/12/2024
... Dumont, B., Terradot, L., Cascales, E., Van Melderen, L., Jurėnas, D. "Thioredoxin 1 moonlights as a chaperone for an interbacterial ADP-ribosyltransferase toxin" Nature Communications., 15: art.n° 10388. (2024). ...
Synthesis, structural elucidation, and DNA binding behavior of a ternary copper(II) complex featuring substituted bipyridyl and dicarboxylate ligands
Publié le 28/11/2024
... Rahaman, S.K., Chatterjee, T., Shaikh, K., Khan, S., Siddiqui, M.R., Wabaidur, S.M., Islam, M.M., Alam, S.M., Mir, M.H. "Synthesis, structural elucidation, and DNA binding behavior of a ternary copper(II) complex featuring substituted bipyridyl and ...
A Macrocycle-Mediated Protein Cage
Publié le 28/11/2024
... Flood, R.J., Thureau, A., Crowley, P.B. "A Macrocycle-Mediated Protein Cage" ACS Macro Letters., 13(12): 1686–1690. (2024). ...
Molecular dynamics and machine learning stratify motion-dependent activity profiles of S-layer destabilizing nanobodies
Publié le 28/11/2024
... Cecil, A.J., Sogues, A., Gurumurthi, M., Lane, K.S., Remaut, H., Pak, A.J. "Molecular dynamics and machine learning stratify motion-dependent activity profiles of S-layer destabilizing nanobodies" PNAS Nexus., 3(12): art.n° pgae538. (2024). ...
Une encre aqueuse pour l’énergie solaire
Publié le 25/11/2024
... Les cellules photovoltaïques organiques (OPVs) présentent plusieurs avantages par rapport aux cellules solaires en silicium, notamment leur flexibilité, leur faible coût et leur légèreté. Cependant, les solvants halogénés utilisés dans leur ...
Dimerization of ADAR1 modulates site-specificity of RNA editing
Publié le 22/11/2024
... Mboukou, A., Rajendra, V., Messmer, S., Mandl, T.C., Catala, M., Tisné, C., Jantsch, M.F., Barraud, P. "Dimerization of ADAR1 modulates site-specificity of RNA editing" Nature Communications., 15: art.n° 10051. (2024). ...
Achieving High Affinity for a Bacterial Lectin with Reversible Covalent Ligands
Publié le 05/11/2024
... Antonini, G., Bernardi, A., Gillon, E., Dal Corso, A., Civera, M., Belvisi, L., Varrot, A., Mazzotta, S. "Achieving High Affinity for a Bacterial Lectin with Reversible Covalent Ligands" Journal of Medicinal Chemistry., 67(21): 19546-19560. (2024). ...