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Diterpenoids from Euphorbia dulcis with Potassium Ion Channel Inhibitory Activity with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effect
Publié le 27/11/2018
... Kúsz, N., Orvos, P., Bereczki, L., Fertey, P., Bombicz, P., Csorba, A., Tálosi, L., Jakab, G., Hohmann, J., Rédei, D. "Diterpenoids from Euphorbia dulcis with Potassium Ion Channel Inhibitory Activity with Selective G Protein-Activated Inwardly Rectifying ...
The reaction mechanism of metallo-β-Lactamases is tuned by the conformation of an active site mobile loop
Publié le 31/10/2018
... Palacios, A.R., Mojica, M.F., Giannini, E., Taracila, M.A., Bethel, C.R., Alzari, P.M., Otero, L.H., Klinke, S., Llarrull, L.I., Bonomo, R.A., Vila, A.J. "The reaction mechanism of metallo-β-Lactamases is tuned by the conformation of an active site mobile ...
Structure and genome ejection mechanism of Podoviridae phage P68 infecting Staphylococcus aureus
Publié le 31/10/2018
... Hrebik, D., Stverakova, D., Skubnik, K., Fuzik, T., Pantucek, R., Plevka, P. "Structure and genome ejection mechanism of Podoviridae phage P68 infecting Staphylococcus aureus". BioRxiv., preprint: (2018). ...
Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography
Publié le 31/10/2018
... de Aguiar Amaral, P., Autheman, D., Dias de Melo, G., Gouault, N., Cupif, J.F., Goyard, S., Dutra, P., Coatnoan, N., Cosson, A., Monet, D., Saul, F., Haouz, A., Uriac, P., Blondel, A., Minoprio, P. "Designed mono- and di-covalent inhibitors trap modeled ...
Genetic and Biochemical Characterization of OXA-535, a Distantly Related OXA-48-Like β-Lactamase
Publié le 31/10/2018
... Dabos, L., Jousset, A.B., Bonnin, R.A., Fortineau, N., Zavala, A., Retailleau, P., Iorga, B.I., Naas, T. "Genetic and Biochemical Characterization of OXA-535, a Distantly Related OXA-48-Like β-Lactamase" Antimicrobial Agents Chemotherapy., 62(10): art.n° ...
The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase
Publié le 30/10/2018
... Castro-Rodrigues, A.F., Zhao, Y., Fonseca, F., Gabant, G., Cadene, M., Robertson, G.A., Morais-Cabral, J.H. "The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of ...
Dissociation of the dimer of the intrinsically disordered domain of RNase Y upon antibody binding
Publié le 29/10/2018
... Hardouin, P., Velours, C., Bou-Nader, C., Assrir, N., Laalami, S., Putzer, H., Durand, D., Golinelli-Pimpaneau, B. "Dissociation of the dimer of the intrinsically disordered domain of RNase Y upon antibody binding" Biophysical Journal., 115(11): 2102 ...
Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants
Publié le 24/10/2018
... Marek, M., Shaik, T.B., Heimburg, T., Chakrabarti, A., Lancelot, J., Ramos Morales, E., Da Veiga, C., Kalinin, D.V., Melesina, J., Robaa, D., Schmidtkunz, K., Suzuki, T., Holl, R., Ennifar, E., Pierce, R., Jung, M., Sippl, W., Romier, C. "Characterization ...
The laterally-acquired GH5 ZgEngAGH5_4 from the marine bacterium Zobellia galactanivorans is dedicated to hemicellulose hydrolysis
Publié le 23/10/2018
... Dorival, J., Ruppert, S., Gunnoo, M., Orłowski,A., Chapelais-Baron,M., Dabin,J., Labourel,A., Thompson,D., Michel,G., Czjzek,M., Genicot, S. "The laterally-acquired GH5 ZgEngAGH5_4 from the marine bacterium Zobellia galactanivorans is dedicated to ...
Qu'a apporté SOLEIL dans le domaine des diagnostics et pronostics médicaux ?
Publié le 18/10/2018
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En lien étroit avec le monde hospitalier, SOLEIL participe à l’élaboration de diagnostics précoces des maladies, et s’intéresse au développement des pathologies, avec en ligne de mire des traitements plus ...