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Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach
Publié le 30/04/2022
... Iannelli, G., Milite, C., Marechal, N., Cura, V., Bonnefond, L., Troffer-Charlier, N., Feoli, A., Rescigno, D., Wang, Y., Cipriano, A., Viviano, M., Bedford, M.T., Cavarelli, J., Castellano, S., Sbardella, G. "Turning Nonselective Inhibitors of Type I ...
L-tyrosine-bound ThiH structure reveals C–C bond break differences within radical SAM aromatic amino acid lyases
Publié le 30/04/2022
... Amara, P., Saragaglia, C., Mouesca, J.M., Martin, L., Nicolet, Y. "L-tyrosine-bound ThiH structure reveals C–C bond break differences within radical SAM aromatic amino acid lyases" Nature Communications., 13: art.n° 2284. (2022). ...
ComFC mediates transport and handling of single-stranded DNA during natural transformation
Publié le 15/04/2022
... Damke, P.P., Celma, L., Kondekar, S.M., Di Guilmi, A.M., Marsin, S., Dépagne, J., Veaute, X., Legrand, P., Walbott, H., Vercruyssen, J., Guérois, R., Quevillon-Cheruel, S., Radicella, J.P. "ComFC mediates transport and handling of single-stranded DNA ...
Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins
Publié le 05/04/2022
... Zhu, Y., Alvarez, F., Wolff, N., Mechaly, A., Brûlé, S., Neitthoffer, B., Etienne-Manneville, S., Haouz, A., Boëda, B., Caillet-Saguy, C. "Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95 ...
Unidirectional mannitol synthesis of Acinetobacter baumannii MtlD is facilitated by the helix–loop–helix-mediated dimer formation
Publié le 05/04/2022
... Tam, H.K., König, P., Himpich, S., Ngu, N.D., Abele, R., Müller, V., Pos, K.M. "Unidirectional mannitol synthesis of Acinetobacter baumannii MtlD is facilitated by the helix–loop–helix-mediated dimer formation" PNAS., 119(14): art.n° e2107994119. (2022). ...
Structural dynamics of the C-terminal X domain of Nipah and Hendra viruses controls the attachment to the C-terminal tail of the nucleocapsid protein
Publié le 01/04/2022
... Bourhis, J.M., Yabukarski, F., Communie, G., Schneider, R., Volchkova, V.A., Frénéat, M., Gérard, F., Ducournau, C., Mas, C., Tarbourie, N., Ringkjøbing Jensen, M., Volchkov, V.E., Blackledge, M., Jamin, M. "Structural dynamics of the C-terminal X domain ...
CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation
Publié le 31/03/2022
... Carrasco, K., Montersino, C., Derviaux, C., Saez-Ayala, M., Hoffer, L., Restouin, A., Castellano, R., Casassa, J., Roche, P., Pasquier, E., Combes, S., Morelli, X., Collette, Y., Betzi, S. "CRCM5484: A BET-BDII Selective Compound with Differential Anti ...
Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development
Publié le 29/03/2022
... Manickam, Y., Malhotra, N., Mishra,S., Babbar, P., Dusane, A., Laleu, B., Bellini, V., Hakimi, M.A., Bougdour, A., Sharma, A. "Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development" PLoS Pathogens., 18(3): ...
Role of human salivary enzymes in bitter taste perception
Publié le 25/03/2022
... Schwartz, M., Brignot, H., Feron, G., Hummel, T., Zhu, Y., von Koskull, D., Heydel, J.M., Lirussi, F., Canon, F., Neiers, F. "Role of human salivary enzymes in bitter taste perception" Food Chemistry., 386: art.n° 132798. (2022). ...
Structure–function relationship of a novel fucoside-binding fruiting body lectin from Coprinopsis cinerea exhibiting nematotoxic activity
Publié le 24/03/2022
... Bleuler-Martinez, S., Varrot, A., Olieric, V., Schubert, M., Vogt, E., Fetz, C., Wohlschlager, T., Plaza, D.F., Wälti, M., Duport, Y., Capitani, G., Aebi, M., Künzler, M. "Structure–function relationship of a novel fucoside-binding fruiting body lectin ...