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Structural insight into the novel Thermus thermophilus SPOUT methyltransferase RlmR catalysing Um2552 formation in the 23S rRNA A-loop: a case of convergent evolution
Publié le 03/06/2025
... Tanouti, Y., Roovers, M., Wolff, P., Lechner, A., Van Elder, D., Feller, A., Soin, R., Gueydan, C., Kruys, V., Droogmans, L., Labar, G. "Structural insight into the novel Thermus thermophilus SPOUT methyltransferase RlmR catalysing Um2552 formation in the ...
Structural basis of G-quadruplex recognition by a camelid antibody fragment
Publié le 03/06/2025
... Pevec, M., Medved, T., Kovačič, M., Žerjav, N., Imperl, J., Plavec, J., Lah, J., Loris,R., Hadži, S. "Structural basis of G-quadruplex recognition by a camelid antibody fragment" Nucleic Acids Research., 53(10): art.n° gkaf453. (2025). ...
Epitope-focused immunogens targeting the hepatitis C virus glycoproteins induce broadly neutralizing antibodies
Publié le 03/06/2025
... Nagarathinam, K., Scheck, A., Labuhn, M., Ströh, L.J., Herold, E., Veselkova, B., Tune, S., Cramer, J.T., Rosset, S., Vollers, S.S., Bankwitz, D., Ballmaier, M., Böning, H., Roth, E., Khera, T., Ahsendorf-Abidi, H.P., Dittrich-Breiholz, O., Obleser, J., ...
The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation
Publié le 03/06/2025
... Grzela, R., Nusbaum, J., Fieulaine, S., Lavecchia, F., Bienvenut, W.V., Dian, C., Meinnel, T., Giglione, C. "The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation" Scientific ...
Structural Insights into a Fusion Protein between a Glutaredoxin-like and a Ferredoxin-Disulfide Reductase Domain from an Extremophile Bacterium
Publié le 29/05/2025
... Zannini, F., Mathiot, S., Couturier, J., Didierjean, C., Rouhier, N. "Structural Insights into a Fusion Protein between a Glutaredoxin-like and a Ferredoxin-Disulfide Reductase Domain from an Extremophile Bacterium" Inorganics., 10(2): art.n° 24. (2022). ...
Ycf48 involved in the biogenesis of the oxygen-evolving photosystem II complex is a seven-bladed beta-propeller protein
Publié le 29/05/2025
... Yu, J., Knoppová, J., Michoux, F., Bialek, W., Cota, E., Shukla, M.K., Strašková, A., Aznar, G.P., Sobotka, R., Komenda, J., Murray, J.W., Nixon, P.J. "Ycf48 involved in the biogenesis of the oxygen-evolving photosystem II complex is a seven-bladed beta ...
Developing nanobodies as allosteric molecular chaperones of glucocerebrosidase function
Publié le 27/05/2025
... Dal Maso, T., Sinisgalli, C., Zilio, G., Franzin, E., Tessari, I., Pardon, E., Steyaert, J., Ballet, S., Greggio, E., Versées, W., Plotegher, N. "Developing nanobodies as allosteric molecular chaperones of glucocerebrosidase function" Nature ...
Probing Macromolecular Interactions by Loss of Solvent Content in Protein Crystals: Application to the Amyloid-β Peptide Binding to Transthyretin
Publié le 23/05/2025
... Costa-Rodrigues, D., Leite, J.P., Gales, L. "Probing Macromolecular Interactions by Loss of Solvent Content in Protein Crystals: Application to the Amyloid-β Peptide Binding to Transthyretin" Crystal Growth & Design., 25(10): 3511-3517 . (2025). ...
Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists
Publié le 23/05/2025
... Amaudrut, J., Argiriadi, M.A., Barth, M., Breinlinger, E.C., Bressac, D., Broqua, P., Calderwood, D.J., Chatar, M., Cusack, K.P., Gauld, S.B., Jacquet, S., Kamath, R.V., Kort, M.E., Lepais, V., Luccarini, J.M., Masson, P., Montalbetti, C., Mounier, L., ...
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
Publié le 23/05/2025
... Tron, A.E., Belmonte, M.A., Adam, A., Aquila, B.M., Boise, L.H., Chiarparin, E., Cidado, J., Embrey, K.J., Eric Gangl, E., Gibbons, F.D., Gregory, G.P., Hargreaves, D., Hendricks, J.A., Johannes, J.W., Johnstone, R.W., Kazmirski, S.L., Kettle, J.G., Lamb, ...