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Qu'a apporté SOLEIL dans le domaine des diagnostics et pronostics médicaux ?

Publié le 18/10/2018
...   En lien étroit avec le monde hospitalier, SOLEIL participe à l’élaboration de diagnostics précoces des maladies, et s’intéresse au développement des pathologies, avec en ligne de mire des traitements plus ...

Targeting an Aromatic Hotspot in Plasmodium falciparum 1‐Deoxy‐d‐xylulose‐5‐phosphate Reductoisomerase with β‐Arylpropyl Analogues of Fosmidomycin

Publié le 17/10/2018
... Sooriyaarachchi, S., Chofor, R., Risseeuw, M.D., Bergfors, T., Pouyez, J., Dowd, C.S., Maes, D., Wouters, J., Jones, T.A., Van Calenbergh, S., Mowbray, S.L. "Targeting an Aromatic Hotspot in Plasmodium falciparum 1‐Deoxy‐d‐xylulose‐5‐phosphate ...

Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors

Publié le 17/10/2018
... Rondelet, G., Fleury, L., Faux, C., Masson, V., Dubois, J., Arimondo, P.B., Willems, L., Wouters, J. "Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors" Future Medicinal Chemistry., 9(13): 1465 ...

Targeting Dynamical Binding Processes in the Design of Non-Antibiotic Anti-Adhesives by Molecular Simulation—The Example of FimH

Publié le 17/10/2018
... Krammer, E.M., de Ruyck, J., Roos, G., Bouckaert, J., Lensink, M.F. "Targeting Dynamical Binding Processes in the Design of Non-Antibiotic Anti-Adhesives by Molecular Simulation—The Example of FimH" Molecules., 23(7): art.n° 1641. (2018). ...

Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis

Publié le 17/10/2018
... El Ghachi, M., Howe, N., Huang, C.Y., Olieric, V., Warshamanage, R., Touzé, T., Weichert, D., Stansfeld, P.J., Wang, M., Kerff, F., Caffrey, M. "Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis" Nature ...

Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis

Publié le 17/10/2018
... El Ghachi, M., Howe, N., Auger, R., Lambion, A., Guiseppi, A., Delbrassine, F., Manat, G., Roure, S., Peslier, S., Sauvage, E., Vogeley, L., Rengifo-Gonzalez, J.C., Charlier, P., Mengin-Lecreulx, D. "Crystal structure and biochemical characterization of ...

Molecular Mechanisms of Drug Action: X-ray Crystallography at the Basis of Structure-based and Ligand-based Drug Design

Publié le 17/10/2018
... de Ruyck, J., Roos, G., Krammer, E.M., Prévost, M., Lensink, M.F., Bouckaert, J. "Molecular Mechanisms of Drug Action: X-ray Crystallography at the Basis of Structure-based and Ligand-based Drug Design" In Biophysical Techniques in Drug Discovery: 67-86: ...

Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Publié le 17/10/2018
... Chofor, R., Sooriyaarachchi, S., Risseeuw, M.D., Bergfors, T., Pouyez, J., Johny, C., Haymond, A., Everaert, A., Dowd, C.S., Maes, L., Coenye, T., Alex, A., Couch, R.D., Jones, T.A., Wouters, J., Mowbray, S.L., Van Calenbergh, S. "Synthesis and ...

Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1

Publié le 17/10/2018
... Bloch, Y., Bouchareychas, L., Merceron, R., Składanowska,K., Van den Bossche,L., Detry,S., Govindarajan,S., Elewaut,D., Haerynck,F., Dullaers,M., Adamopoulos,I.E., Savvides, S.N. "Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate ...

Photoionization of the iodine 3d, 4s, and 4p orbitals in methyl iodide

Publié le 10/10/2018
... Forbes, R., De Fanis, A., Bomme, C., Rolles, D., Pratt, S.T., Powis, I., Besley, N.A., Simon, M., Nandi, S., Milosavljević,A.R., Nicolas,C., Bozek, J.D., Underwood,J.G., Holland, D.M.P. "Photoionization of the iodine 3d, 4s, and 4p orbitals in methyl ...