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A new chemotype that opens the S2* pocket of the 3CL protease exhibits antiviral activity against SARS-CoV-2.
Publié le 30/10/2025
... Mourot, L., Chaibi, F.Z., Bou-Karroum, N., Carré, P., Abengozar Munoz, A., Landry, V., Tarricone, A., Biela, A., Piveteau, C., Novikov, G., Dupré, E., Dubuisson, J., Belouzard, S., Leroux, F., Deprez, B., Hanoulle, X., Charton, J. "A new chemotype that ...
Structural and Spectroscopic Insights into Catalytic Intermediates of a [NiFe]-hydrogenase from Group 3
Publié le 15/10/2025
... Jespersen, M., Lorent, C., Lemaire, O.N., Zebger, I., Wagner, T. "Structural and Spectroscopic Insights into Catalytic Intermediates of a [NiFe]-hydrogenase from Group 3" ChemBioChem., 26(21): art.n° e202500692. (2025). ...
Une nouvelle cible pour traiter le virus mpox (variole du singe) et d’autres infections poxvirales
Publié le 10/09/2025
... Le mpox est une maladie infectieuse transmise par contact, pouvant être mortelle ou laisser des séquelles importantes. Des chercheurs de l’Institut Pasteur ont identifié et caractérisé une nouvelle cible pour développer des thérapies capables ...
Fidelity, specialization, and evolution of Paramecium PolX DNA polymerases involved in programmed double-strand break DNA repair
Publié le 20/08/2025
... Nourisson, A., Missoury, S., Lucas-Staat, S., Haouz, A., Delarue, M. "Fidelity, specialization, and evolution of Paramecium PolX DNA polymerases involved in programmed double-strand break DNA repair" Nucleic Acids Research., 53(15): art.n° gkaf786. (2025 ...
Revealing Ligand Deprotonation and Speciation Pathways in Cu(II)–Glycine Aqueous Solutions via Liquid-Jet X-ray Photoelectron Spectroscopy Supported by ab-initio Calculations
Publié le 20/08/2025
... Céolin, D., Saisopa, T., Rattanachai, Y., Tangsukworakhun, S., Pokapanich, W., Songsiriritthigul, P., Songsiriritthigul, S., Klaiphet, K., Palaudoux, J., Nicolas, C., Carniato, S. "Revealing Ligand Deprotonation and Speciation Pathways in Cu(II)–Glycine ...
Crystal structure of the virulence protein J (VirJ) domain 1 from Brucella abortus
Publié le 19/08/2025
... Dugelay, C., Ferrarin, S., Terradot, L. "Crystal structure of the virulence protein J (VirJ) domain 1 from Brucella abortus" Acta Crystallographica F., 81(9): 374-380. (2025). ...
Valence photoelectron spectra of thiouracils in the gas phase
Publié le 19/08/2025
... Mayer, D., Titov, E., Lever, F., Mehner, L., Murillo-Sánchez, M.L., Walz, C., Bozek, J.D., Saalfrank, P., Gühr, M. "Valence photoelectron spectra of thiouracils in the gas phase" Journal of Chemical Physics., 163(7): art.n° 074301. (2025). ...
Ionic photofragmentation cross sections of the HS + , H 2 S + and HCl + molecular ions near the 2p threshold
Publié le 14/08/2025
... Mosnier, J.P., Kennedy, E.T., Cubaynes, D., Bizau, J.M., Guilbaud, S., Carniato, S. "Ionic photofragmentation cross sections of the HS + , H 2 S + and HCl + molecular ions near the 2p threshold" PCCP - Physical Chemistry Chemical Physics., 27(35): 18595 ...
Structural and Enzymological Characterization of Phosphoserine Phosphatase From Brucella melitensis
Publié le 13/08/2025
... Scaillet, T., Pierson, E., Fillet, M., Wouters, J. "Structural and Enzymological Characterization of Phosphoserine Phosphatase From Brucella melitensis" Proteins Structure Function and Bioinformatics., 94(2): 502-514. (2026). ...
Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target
Publié le 13/08/2025
... Ketprasit, N., Tai, C.W., Sharma, V.K., Manickam, Y., Khandokar, Y., Ye, X., Dogovski, C., Hilko,D.H., Morton, C.J., Braun, A.S.C., Leeming, M.G., Siddharam, B., Shami, G.J., Pradeepkumar, P.I., Panjikar, S., Poulsen, S.A., Griffin, M.D.W., Sharma, A., ...