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Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach
Publié le 30/04/2022
... Iannelli, G., Milite, C., Marechal, N., Cura, V., Bonnefond, L., Troffer-Charlier, N., Feoli, A., Rescigno, D., Wang, Y., Cipriano, A., Viviano, M., Bedford, M.T., Cavarelli, J., Castellano, S., Sbardella, G. "Turning Nonselective Inhibitors of Type I ...
L-tyrosine-bound ThiH structure reveals C–C bond break differences within radical SAM aromatic amino acid lyases
Publié le 30/04/2022
... Amara, P., Saragaglia, C., Mouesca, J.M., Martin, L., Nicolet, Y. "L-tyrosine-bound ThiH structure reveals C–C bond break differences within radical SAM aromatic amino acid lyases" Nature Communications., 13: art.n° 2284. (2022). ...
Virus hémorragique de Crimée-Congo – Résultats de biologie structurale pour de futurs vaccins et traitements
Publié le 29/04/2022
... La fièvre hémorragique de Crimée-Congo (FHCC) tient son nom d’une première description de cette maladie en Crimée en 1944, chez des militaires soviétiques, puis au Congo en 1956. Transmise à l’Homme par piqûre de tique ou contact direct avec ...
Advances in Vitamin D Receptor Function and Evolution Based on the 3D Structure of the Lamprey Ligand-Binding Domain
Publié le 29/04/2022
... Sigüeiro, R., Bianchetti, L., Peluso-Iltis, C., Chalhoub, S., Dejaegere, A., Osz, J., Rochel, N. "Advances in Vitamin D Receptor Function and Evolution Based on the 3D Structure of the Lamprey Ligand-Binding Domain" Journal of Medicinal Chemistry., 65(7) ...
The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor
Publié le 15/04/2022
... Fernández, F.J., Santos-López, J., Martínez-Barricarte, R., Querol-García, J., Martín-Merinero, H., Navas-Yuste, S., Savko, M., Shepard, W.E., Rodríguez de Córdoba, S., Vega, M.C. "The crystal structure of iC3b-CR3 αI reveals a modular recognition of the ...
ComFC mediates transport and handling of single-stranded DNA during natural transformation
Publié le 15/04/2022
... Damke, P.P., Celma, L., Kondekar, S.M., Di Guilmi, A.M., Marsin, S., Dépagne, J., Veaute, X., Legrand, P., Walbott, H., Vercruyssen, J., Guérois, R., Quevillon-Cheruel, S., Radicella, J.P. "ComFC mediates transport and handling of single-stranded DNA ...
Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins
Publié le 05/04/2022
... Zhu, Y., Alvarez, F., Wolff, N., Mechaly, A., Brûlé, S., Neitthoffer, B., Etienne-Manneville, S., Haouz, A., Boëda, B., Caillet-Saguy, C. "Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95 ...
Unidirectional mannitol synthesis of Acinetobacter baumannii MtlD is facilitated by the helix–loop–helix-mediated dimer formation
Publié le 05/04/2022
... Tam, H.K., König, P., Himpich, S., Ngu, N.D., Abele, R., Müller, V., Pos, K.M. "Unidirectional mannitol synthesis of Acinetobacter baumannii MtlD is facilitated by the helix–loop–helix-mediated dimer formation" PNAS., 119(14): art.n° e2107994119. (2022). ...
CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation
Publié le 31/03/2022
... Carrasco, K., Montersino, C., Derviaux, C., Saez-Ayala, M., Hoffer, L., Restouin, A., Castellano, R., Casassa, J., Roche, P., Pasquier, E., Combes, S., Morelli, X., Collette, Y., Betzi, S. "CRCM5484: A BET-BDII Selective Compound with Differential Anti ...
The X-ray crystallography phase problem solved thanks to AlphaFold and RoseTTAFold models: a case-study report
Publié le 18/03/2022
... Barbarin-Bocahu, I., Graille, M. "The X-ray crystallography phase problem solved thanks to AlphaFold and RoseTTAFold models: a case-study report" Acta Crystallographica D., 78(4): 517-531. (2022). ...