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Biologie, Santé - HelioBio


Welcome to HelioBio!

Membres heliobio The HelioBio section at SOLEIL, being strongly inter-disciplinary and also at the junction where scientific measurement and project meet, is a natural focal point for the development of innovative methods in order to help advance the most difficult « external user » research. This is of critical importance in the highly competitive and labour intensive field of the biological sciences, where methodological improvements (which help make the most of the available samples) can make the difference between success and failure, or publishing first or second. Several very important publications, which would otherwise not have been achieved in such a timely fashion, have resulted from this symbiosis between beamline scientist and user at SOLEIL.

Bio-microspectroscopy Biomacromolecules

HelioBio Team

HelioBio section responsible
HelioBio Secretary
Cell Biology
HelioBio Secretary
X-ray tomography
Structural bioinformatics
Biology lab. responsible
Mass spectrometry
Mass spectrometry
Proteins cristallography
Cell biology
Infrared micro-spectroscopy
X-ray tomography
Infrared micro-spectroscopy
MX and 3D sample modelling
 Macromolecular cristallography
Scientific director
SR Circular Dichroism
SR Circular Dichroism
Beamline Engineering
Multimodal nano-X-ray imaging
X-ray tomography

Les lignes de lumière de la section




Scientific axes Experimental techniques Techniques of analysis


structural and cell


green technologies


Structure of biomacromolecules :
X-Ray (Imaging),
Christallography (Diffraction),
SAXS (Scattering),
  • IR Microscopy
  • X-ray tomography
  • Fluorescence imaging
  • Photoemission electron microscopy (PEEM)

  • Crystallography (material science)
  • Crystallography (biological macromolecules)

  • UV circular dichroism (UVCD)
  • Time-resolved studies
  • X Ray Magnetic Circular Dichroism (XMCD)

  • Small angle scattering (SAXS)
Infrared, DUV, X-Ray
X-Ray Imaging Coherent,
full field,
scanning nanoprobres


Deep PDT

Photodynamic therapy for deep seated malignancies where the X-ray as external light source is used. This unique therapy relies on activation of scintillation nanoparticles via x-ray excitation to produce optical emission that subsequently activates a photosensitizer (light sensitive drug). The activated photosensitizer produces singlet oxygen species resulting in cancer cell destruction.
Contact: Matthieu Refregiers

All HelioBio News from Health



Characterisation of living fully-hydrated stem cells by vibrational microspectroscopy

Induced pluripotent stem cells are obtained by the genetic reprogramming of differentiated adult cells and could provide an unending reservoir of biocompatible cells for medical applications without the destruction of embryos. We work on methods for characterization of the cell ‘stemness’, for the detection of the potentially carcinogenic cells, and for quality control during reprogramming and differentiation in medically relevant cells using vibrational microspectroscopies, infrared and Raman.
Contact: Christophe Sandt

RNA degradation in trypanosomatids

Trypanosomes and leishmanias cause a number of serious diseases in humans and other animals. One of the remarkable features of these parasites is the lack of transcription control. The project aims at the structural characterization of proteins and complexes involved in the mRNA degradation in kinetoplastids, one of the mechanisms available for these parasites to regulate gene expression. 
Contact: Beatriz Guimarães

All HelioBio News from Biology



Rapsseed Olesomes Extraction

Lipids of plant seeds are stored in specialized organelles called oleosomes structured by oleosin membrane proteins (S1 to S5). These proteins, for which a detailed 3D structure is unknown, are inserted into a monolayer of phospholipids.
Using SRCD we have shown, that recombinant oleosin S5, solubilized by polymeric surfactants called amphipols, contains more beta and less alpha structures as compared with the fold in SDS. The same work has now been done with S3 oleosin, the more abundant oleosin in plants. In order to decipher the in vivo fold, we studied the secondary structure of oleosins in oil bodies: purified from A. thaliana, from yeast, or artificial ones. SRCD resvealed the structural oleosome assembly and stability. The goal is to develop milder methods for seed oil extraction, and to design new and natural emulsion stabilizers.
Contact: Frank Wien

All HelioBio News from Agroscience



Amis et collaborations

Le logo d'INRAE




Prochains séminaires

March 9th, 2020

Analysis of the dynamics of the acetylcholinesterase without and with inhibitor seen by quasi-elastic neutron scattering by Melek Saouessi (Centre de Biophysique Moléculaire, CNRS - Orléans)

PDF icon Abstract_Saouessi (104.01 Ko)

March 23rd, 2020 Molecular organization and regulation of the Usher2 complex, a protein assembly related to deafness and blindness by Nicolas Wolff (Institut Pasteur)  

For external people, please contact for access formalities.

Séminaires passés

March 2nd, 2020 Infrared and proteins by Christophe Sandt (SMIS beamline, SOLEIL) PDF icon Abstract_Sandt (193.08 Ko)
September 28th, 2017

Local and Dynamic Investigations for Bio-soft materials at SPring-8 by Hiroshi SEKIGUCHI (Japan Synchrotron Research Institute JASRI / SPring-8).

PDF icon Abstract_Sekiguchi (179.01 Ko)
June 26th, 2017 Bio-inspired self-assemblies: from artificial chaperones to responsive protocells by Nicolas Martin (University of Bristol, UK). PDF icon (93.87 Ko)
June 19th, 2017
Singlet oxygen generation enhancement by pectin coated silver nanoparticles for improved photosensitization efficiency in photodynamic therapy by Maria Bélen Rivas Aiello (National University of La Plata, Argentina). PDF icon Abstract Rivas-Aiello (102.1 Ko)
May 22nd, 2017
In vitro reconstitution and characterization of actomyosin-dependent mechanosensitive machineries associated with adhesion complexes by Christophe Le Clainche (Institut de Biologie Intégrative de la Cellule - I2BC, Gif-sur-Yvette). PDF icon Abstract Le Clainche (104.86 Ko)
April 18th, 2017

Bioinformatics: Structure-Function-Evolution.From molecular chaperones and protein folding to SAXS and membrane proteins by Maciej Baranowski (SWING beamline, SOLEIL).

PDF icon (93.99 Ko)
March 28th, 2017 Diffraction anisotropy of membrane protein crystals is not dependent on the crystallization method, on the type of membrane protein, or on the presence of extra-membranous domains, and suggests a biological implication to this physical phenomenon by Vincent Chaptal (Institute of Biology and Chemistry of Proteins - IBCP, Lyon).  
March 6th, 2017

Lessons from (co)evolution in the structural modeling and design of protein interactions by Jessica Andreani and Raphaël Guerois (Laboratory of Structural Biology and Radiobiology LBSR, IBITECS CEA Saclay).

PDF icon Abstract_Andreani-Guerois (294.34 Ko)