Welcome to HelioBio!
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The HelioBio section at SOLEIL, being strongly inter-disciplinary and also at the junction where scientific measurement and project meet, is a natural focal point for the development of innovative methods in order to help advance the most difficult « external user » research. This is of critical importance in the highly competitive and labour intensive field of the biological sciences, where methodological improvements (which help make the most of the available samples) can make the difference between success and failure, or publishing first or second. Several very important publications, which would otherwise not have been achieved in such a timely fashion, have resulted from this symbiosis between beamline scientist and user at SOLEIL. |
HelioBio Team
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Structural bioinformatics
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Biology lab. responsible
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Mass spectrometry
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Infrared micro-spectroscopy
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SAXS
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X-ray tomography
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HPLC-MALLS-RI
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Scientific director
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SR Circular Dichroism
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SAXS
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SR Circular Dichroism
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Beamline Engineering
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Multimodal nano-X-ray imaging
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X-ray tomography
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Les lignes de lumière de la section
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Fil twitter
- Heliobio follows "What can cryo electron tomography and cryo soft X-ray tomography do? From the basics to correlati… https://t.co/AQrYtQ11MD
- First high resolution crystal structure of the apo form of the lectin N-terminal domain (BC2L-C-nt) using a drugga… https://t.co/RBEiIo7FPH
- Great study of @I2BCParisSaclay @OFrancoiz @iecb_bordeaux to find an optimal anchoring of a foldamer inhibitor of A… https://t.co/GZlScdJ6iu
- @synchroSOLEIL @AdvSciNews @PROXIMA_1 @DiscoBeamline @SwingBeamline Nice project of #integrative_biology
| Scientific axes | Experimental techniques | Techniques of analysis | ||
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Medicine
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Biology
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Agrosciences
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Structure of biomacromolecules : X-Ray (Imaging), Christallography (Diffraction), SAXS (Scattering), SRCD APPI |
Imaging
Diffraction
Absorption
Scattering
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| Spectromicroscopy Infrared, DUV, X-Ray |
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| X-Ray Imaging Coherent, Tomography, full field, scanning nanoprobres |
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Health
Deep PDT
Photodynamic therapy for deep seated malignancies where the X-ray as external light source is used. This unique therapy relies on activation of scintillation nanoparticles via x-ray excitation to produce optical emission that subsequently activates a photosensitizer (light sensitive drug). The activated photosensitizer produces singlet oxygen species resulting in cancer cell destruction.
Contact: Matthieu Refregiers
Biology
Characterisation of living fully-hydrated stem cells by vibrational microspectroscopy
Induced pluripotent stem cells are obtained by the genetic reprogramming of differentiated adult cells and could provide an unending reservoir of biocompatible cells for medical applications without the destruction of embryos. We work on methods for characterization of the cell ‘stemness’, for the detection of the potentially carcinogenic cells, and for quality control during reprogramming and differentiation in medically relevant cells using vibrational microspectroscopies, infrared and Raman.
Contact: Christophe Sandt
RNA degradation in trypanosomatids
Trypanosomes and leishmanias cause a number of serious diseases in humans and other animals. One of the remarkable features of these parasites is the lack of transcription control. The project aims at the structural characterization of proteins and complexes involved in the mRNA degradation in kinetoplastids, one of the mechanisms available for these parasites to regulate gene expression.
Contact: Beatriz Guimarães
All HelioBio News from Biology
Agroscience
Rapsseed Olesomes Extraction
Lipids of plant seeds are stored in specialized organelles called oleosomes structured by oleosin membrane proteins (S1 to S5). These proteins, for which a detailed 3D structure is unknown, are inserted into a monolayer of phospholipids.
Using SRCD we have shown, that recombinant oleosin S5, solubilized by polymeric surfactants called amphipols, contains more beta and less alpha structures as compared with the fold in SDS. The same work has now been done with S3 oleosin, the more abundant oleosin in plants. In order to decipher the in vivo fold, we studied the secondary structure of oleosins in oil bodies: purified from A. thaliana, from yeast, or artificial ones. SRCD resvealed the structural oleosome assembly and stability. The goal is to develop milder methods for seed oil extraction, and to design new and natural emulsion stabilizers.
Contact: Frank Wien
Laboratoires
Amis et collaborations
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Prochains séminaires
| March 9th, 2020 |
Analysis of the dynamics of the acetylcholinesterase without and with inhibitor seen by quasi-elastic neutron scattering by Melek Saouessi (Centre de Biophysique Moléculaire, CNRS - Orléans) |
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| March 23rd, 2020 | Molecular organization and regulation of the Usher2 complex, a protein assembly related to deafness and blindness by Nicolas Wolff (Institut Pasteur) |
For external people, please contact camille.rivard@synchrotron-soleil.fr for access formalities.
Séminaires passés
| March 2nd, 2020 | Infrared and proteins by Christophe Sandt (SMIS beamline, SOLEIL) |  Abstract_Sandt (193.08 Ko) |
| September 28th, 2017 |
Local and Dynamic Investigations for Bio-soft materials at SPring-8 by Hiroshi SEKIGUCHI (Japan Synchrotron Research Institute JASRI / SPring-8). |
Abstract_Sekiguchi (179.01 Ko) |
| June 26th, 2017 | Bio-inspired self-assemblies: from artificial chaperones to responsive protocells by Nicolas Martin (University of Bristol, UK). | (93.87 Ko) |
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June 19th, 2017
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Singlet oxygen generation enhancement by pectin coated silver nanoparticles for improved photosensitization efficiency in photodynamic therapy by Maria Bélen Rivas Aiello (National University of La Plata, Argentina). | Abstract Rivas-Aiello (102.1 Ko) |
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May 22nd, 2017
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In vitro reconstitution and characterization of actomyosin-dependent mechanosensitive machineries associated with adhesion complexes by Christophe Le Clainche (Institut de Biologie Intégrative de la Cellule - I2BC, Gif-sur-Yvette). | Abstract Le Clainche (104.86 Ko) |
| April 18th, 2017 |
Bioinformatics: Structure-Function-Evolution.From molecular chaperones and protein folding to SAXS and membrane proteins by Maciej Baranowski (SWING beamline, SOLEIL). |
(93.99 Ko) |
| March 28th, 2017 | Diffraction anisotropy of membrane protein crystals is not dependent on the crystallization method, on the type of membrane protein, or on the presence of extra-membranous domains, and suggests a biological implication to this physical phenomenon by Vincent Chaptal (Institute of Biology and Chemistry of Proteins - IBCP, Lyon). | |
| March 6th, 2017 |
Lessons from (co)evolution in the structural modeling and design of protein interactions by Jessica Andreani and Raphaël Guerois (Laboratory of Structural Biology and Radiobiology LBSR, IBITECS CEA Saclay). |
Abstract_Andreani-Guerois (294.34 Ko) |