Aller au menu principal Aller au contenu principal

Séminaire Upgrade - Radiation Damage in Macromolecular Crystallography: what metrics are useful ?

Partager
24 janvier 2020 10h • Amphithéâtre de SOLEIL

Elspeth GARMAN

(Department of Biochemistry, University of Oxford, UK)


Over twenty years of research into the effects of radiation damage on protein structures both at room temperature and when held at cryo-temperatures has resulted in many interesting and useful observations [reviewed in 1-3] but has still not provided a full understanding of the reported phenomena.

In this talk I will attempt to summarise the current state of knowledge and highlight the challenges in developing robust metrics for characterising the rates of global and specific damage.

 

References

[1] - J.M. Holton, J. Synchrotron Radiation 16, 133–142 (2009)
[2] - E.F. Garman, Acta Cryst  D66, 339-351 (2010)
[3] – E.F. Garman and M. Weik, Chapter 4 in ‘Protein Crystallography: Challenges and Practical Solutions’ Eds: Konstantinos Beis and Gwyndaf Evans, Published Royal Society of Chemistry. Pp 88-116 (2018)

 

Formalités d’entrée :

Accès libre dans l’amphi du pavillon d’Accueil.
Si la manifestation a lieu dans le Grand Amphi SOLEIL du Bâtiment Central merci de vous munir d’une pièce d’identité (à échanger à l’accueil contre un badge d’accès)

Contact : Sandrine Vasseur

Documents à télécharger