Aiwen LEI
(Vice director of the Institute for Advanced Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University, China)
Our research focuses on the oxidative coupling to develop a novel and efficient bond-formation method between two nucleophiles. We have successfully developed three generations of oxidative cross-coupling. In addition, in-depth understanding toward the reactions is the other focus. Recently, we revealed that 1) transmetallation is the rate-determining step in Sonogashira Coupling and the activation enthalpy is obtained; 2) labile Cu(I) catalyst/spectator Cu(II) species existed in Cu-catalyzed C-C coupling using IR, in situ XANES/EXAFS evidence and kinetic investigations; 3) ate-complex is the intermediate in Cu-catalyzed C-H oxidation of benzothiazole using X-Ray absorption spectroscopy; 4) Cu(II) was reduced to Cu(I) species by alkynes in the presence of TMEDA; 5) Cu(II)/Cu(I) synergistic cooperation might be involved in alkyne C−H activation and homocoupling.
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Contact : Sandrine Vasseur