Séminaire - One or Two Electron Redox, Mechanism of Homogenous Catalysis Revealed by EXAFS

Aiwen LEI

(Vice director of the Institute for Advanced  Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University, China)

Our research focuses on the oxidative coupling to develop a novel and efficient bond-formation method between two nucleophiles. We have successfully developed three generations of oxidative cross-coupling. In addition, in-depth understanding toward the reactions is the other focus. Recently, we revealed that 1) transmetallation is the rate-determining step in  Sonogashira Coupling and the activation enthalpy is obtained; 2) labile Cu(I) catalyst/spectator Cu(II) species existed in Cu-catalyzed C-C coupling using IR, in situ XANES/EXAFS evidence and kinetic investigations; 3) ate-complex is the intermediate in Cu-catalyzed C-H oxidation of benzothiazole using X-Ray absorption spectroscopy; 4) Cu(II) was reduced to Cu(I) species by alkynes in the presence of TMEDA; 5) Cu(II)/Cu(I) synergistic cooperation might be involved in alkyne C−H activation and homocoupling.

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