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Identification of an Achilles heel in the dengue virus gives new hope for vaccine development

In association with Imperial College London, scientists at the Institut Pasteur and CNRS have identified a vulnerable site on the surface of the dengue virus which is targeted by the only broadly neutralizing antibodies identified to date. This discovery offers a new target for the development of a vaccine to combat all four types of dengue virus currently in circulation. These results were published in the journal Nature on January 12, 2015.

Illustration: 3D structure of the antibody complexes for all four serotypes bound to the dengue virus envelope protein.
 © Institut Pasteur

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