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Architecture of the Sap S-layer of Bacillus anthracis revealed by integrative structural biology
Publié le 11/12/2024
... Sogues, A., Leigh, K., Halingstad, E.V., Van der Verren, S.E., Cecil, A.J., Fioravanti, A., Pak, A.J., Kudryashev, M., Remaut, H. "Architecture of the Sap S-layer of Bacillus anthracis revealed by integrative structural biology" PNAS., 121(51): art.n° ...
Enzymatic, structural, and biophysical characterization of a single-domain antibody (VHH) selectively and tightly inhibiting neutrophil elastase and exhibiting favorable developability properties
Publié le 04/12/2024
... Redeghieri, P., Moray, J., Kerff, F., Gohy S., Leal, T., Muyldermans, S., Vanbever, R., Morales-Yánez, F.J., Dumoulin, M. "Enzymatic, structural, and biophysical characterization of a single-domain antibody (VHH) selectively and tightly inhibiting ...
Molecular dynamics and machine learning stratify motion-dependent activity profiles of S-layer destabilizing nanobodies
Publié le 28/11/2024
... Cecil, A.J., Sogues, A., Gurumurthi, M., Lane, K.S., Remaut, H., Pak, A.J. "Molecular dynamics and machine learning stratify motion-dependent activity profiles of S-layer destabilizing nanobodies" PNAS Nexus., 3(12): art.n° pgae538. (2024). ...
Dimerization of ADAR1 modulates site-specificity of RNA editing
Publié le 22/11/2024
... Mboukou, A., Rajendra, V., Messmer, S., Mandl, T.C., Catala, M., Tisné, C., Jantsch, M.F., Barraud, P. "Dimerization of ADAR1 modulates site-specificity of RNA editing" Nature Communications., 15: art.n° 10051. (2024). ...
Achieving High Affinity for a Bacterial Lectin with Reversible Covalent Ligands
Publié le 05/11/2024
... Antonini, G., Bernardi, A., Gillon, E., Dal Corso, A., Civera, M., Belvisi, L., Varrot, A., Mazzotta, S. "Achieving High Affinity for a Bacterial Lectin with Reversible Covalent Ligands" Journal of Medicinal Chemistry., 67(21): 19546-19560. (2024). ...
The structure of a Tau fragment bound to tubulin prompts new hypotheses on Tau mechanism and oligomerization
Publié le 31/10/2024
... Ammar Khodja, L., Campanacci, V., Lippens, G., Gigant, B. "The structure of a Tau fragment bound to tubulin prompts new hypotheses on Tau mechanism and oligomerization" PNAS Nexus., 3(11): art.n° 487. (2024). ...
RNase W, a conserved ribonuclease family with a novel active site
Publié le 29/10/2024
... Vayssières, M., Jüttner, M., Haas, K., Ancelin, A., Marchfelder, A., Leulliot, N., Ferreira-Cerca, S., Blaud, M. "RNase W, a conserved ribonuclease family with a novel active site" Nucleic Acids Research., 52(21): 13386–13401. (2024). ...
Ethane-oxidising archaea couple CO2 generation to F420 reduction
Publié le 23/10/2024
... Lemaire, O.N., Wegener, G., Wagner, T. "Ethane-oxidising archaea couple CO2 generation to F420 reduction" Nature Communications., 15: art.n° 9065. (2024). ...
4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
Publié le 17/10/2024
... Calbert, M.L., Chandramouly, G., Adams, C.M., Saez-Ayala, M., Kent, T., Tyagi, M., Abhinav Ayyadevara, V.S.S., Wang, Y., Krais, J.J., Gordon, J., Atkins, J., Toma, M.M., Betzi, S., Boghossian, A.S., Rees, M.G., Ronan, M.M., Roth, J.A., Goldman, A.R., ...
Rational fragment-based design of compounds targeting the PWWP domain of the HRP family
Publié le 11/10/2024
... Vantieghem, T., Aslam, N.A., Osipov, E.M., Akele, M., Van Belle, S., Beelen, S., Drexler, M., Paulovcakova, T., Lux, V., Fearon, D., Douangamath, A., von Delft, F., Christ, F., Veverka, V., Verwilst, P., Van Aerschot, A., Debyser, Z., Strelkov, S.V. ...