Last update : 10.09.2025
Ferchaud, N., Kopečný, D., Peřina,M., Boyer, A., Hentati, S., Pontoizeau, C., Desterke, C., Kryštof,V., Machover,D., Briozzo, P. "The methioninase from the alkalithermophile Thermobrachium celere possesses suitable properties for treatment of cancer" International Journal of Biological Macromolecules., 330(2): art.n° 147876. (2025).
Froes, T.Q., Alegbejo Price, T.O., Fleck Godoi, B., Vaidergorn, M.M., Dos Santos, T., Leite, P.I.P., Silva, D.G., Dias da Purificação, A., Loch, L., Schenkman, S., Kratz, J.M., da Silva Emery, F., Nonato, M.C. "Barbituric Acid Derivatives as Covalent Inhibitors of Leishmania braziliensis Dihydroorotate Dehydrogenase" Journal of Medicinal Chemistry., 68(18): 18869–18884. (2025).
Mann, S.E., Lefranc, J., Alkhatib, O., Boivin, R., Bomke, J., Byrne, R.T., Cassona, C.P., Chen, X., Cornaciu, I., Costales, P., Davis, O.A., DeSelm, L., Elinati, E., Follows, B., Galbiati, A., Goldner, C., Hayre, J.K., Jorand-Lebrun, C., Lademann, C.A., Leuthner, B., Majithiya, J.B., Malta, C.F., Mason, B., McWhirter, C.L., Neff, B., Nissink, J.W.M., Pehl, U., Petersson, C., Pica, A., Pinto, M.F., Rajendra, E., Rakers, C., Toste Rego, A., Robinson, H.M.R., Sala-Hojman, A., Schaedler, T.A., Schurmann, P.J.L., Silva, D.O., Smith, G.C.M., Sorrell, F., Webster, G.R., Zenke, F.T., Heald, R.A., Burgdorf, L.T. "Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor". Journal of Medicinal Chemistry., on line first (07/10/2025): (2025).
Nandwani, N., Bhowmik, D., Glaser, C., Childers, M.C., Goluguri, R.R., Dawood, A., Regnier, M., Houdusse, A., Spudich, J.A., Ruppel, K.M. "Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically" Nature Communications., 16: art.n° 8751. (2025).
Martinkus, J., Terradot, L., Jurėnas, D., Cascales, E. "Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins". Journal of Biological Chemistry., on line first (29/09/2025): (2025).
Vieira Da Cruz, A., Perraudin, V., Minopoli, N., Iacono, R., Roig-Zamboni, V., Bossio, A., Tangara, S., Fayolle, M., Kanazawa, A., Philouze, C., Tarallo, A., Heming, J.J.A., Artola, M., Behr, J.B., Overkleeft, H.S., Moracci, M., Sulzenbacher, G., Parenti, G., Py, S. "C-Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal α-Glucosidase for the Treatment of Pompe Disease" Journal of Medicinal Chemistry., 68(18): 19269–19286. (2025).
Moussawi, M.A., Abdelhameed, S.A.M., de Azambuja, F., Wijten, A., Vasović, T., Ćirković Veličković, T., Parac-Vogt, T.N. "Fast and selective protein modification with ironsubstituted polyoxometalates via a radical pathway". Inorganic Chemistry Frontiers., on line first (26/09/2025): (2025).
Vantieghem, T., Osipov, E.M., Beelen, S., Strelkov, S.V. "Crystal engineering of the hepatoma-derived growth factor-related protein 2 PWWP domain towards crystallographic fragment screening" Acta Crystallographica F., 81(8): 358-364. (2025).
De Colibus, L., Ludzi, P., Biasutto, A., Pica, A., Hopper, J.T.S., Jazayeri, A., Dürr, K.L. "Improved structure of mouse gasdermin D: a new blueprint for structure-based drug design" Acta Crystallographica F., 81(10): 408-415. (2025).
Kalandia, G., Declerck, K., Salazar Marcano, D.E., Gourmand, R., Moussawi, M.A., Parac-Vogt, T.N. "Finding the Key: Binding of Metal-Oxo Clusters to the Enzyme Active Site Enabled by “Click” (Bio)Conjugation". Angewandte Chemie International Edition., on line first (25/09/2025): (2025).