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Upgrade seminar - Radiation Damage in Macromolecular Crystallography: what metrics are useful ?

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January 24, 2020 10h • Amphitheater of SOLEIL

Elspeth GARMAN

(Department of Biochemistry, University of Oxford, UK)


Over twenty years of research into the effects of radiation damage on protein structures both at room temperature and when held at cryo-temperatures has resulted in many interesting and useful observations [reviewed in 1-3] but has still not provided a full understanding of the reported phenomena.

In this talk I will attempt to summarise the current state of knowledge and highlight the challenges in developing robust metrics for characterising the rates of global and specific damage.

 

References

[1] - J.M. Holton, J. Synchrotron Radiation 16, 133–142 (2009)
[2] - E.F. Garman, Acta Cryst  D66, 339-351 (2010)
[3] – E.F. Garman and M. Weik, Chapter 4 in ‘Protein Crystallography: Challenges and Practical Solutions’ Eds: Konstantinos Beis and Gwyndaf Evans, Published Royal Society of Chemistry. Pp 88-116 (2018)

 

Entrance formalities:

Free access in the auditorium of the Reception building.
If the manifestation takes place in the main building thank you for providing an ID card (to exchange at the reception for an access pass)

Contact: Sandrine Vasseur