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Post-doctoral position on PROXIMA-2A beamline : Serial Crystallography Methods on MOF and POM micro-crystals

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SOLEIL is the French national synchrotron facility, located on the Saclay Plateau near Paris, and partner of the Paris-Saclay University. It is a multi-disciplinary instrument and a research laboratory, whose mission is to exploit the use of synchrotron radiation, develop state-of-the-art instrumentation on beamlines, and make them available to the scientific community. SOLEIL, a unique tool for both academic research and industrial applications, is used by over 3,000 researchers from France and abroad, across a wide range of disciplines including physics, biology, chemistry etc... It is based on a state of the art synchrotron source, both in terms of brilliance and stability. The facility is a “public” company founded by the CNRS and the CEA, which employs about 500 people.

PROXIMA 2A is a micro-focus beamline dedicated to macromolecular crystallography (MX), but is also used for chemical crystallography (CX). It delivers a very intense X-ray beam focused down to a few microns (10 µm * 5 µm, H*V FWHM). The X-rays are tunable over a wide energy range (6 – 18 keV), which covers the absorption edges of most heavy atoms for anomalous scattering studies. The end station is equipped with a high performance multi-axis goniometer, a robotic sample changer, a cryostat and an X-ray fluorescence detector. The area detector is an EIGER 9M, which is a fast (238 Hz in 9M mode or 750 Hz in 4M mode), state-of-the-art, photon counting, pixel array detector. PROXIMA 2A serves a large number of academic and industrial users in the international MX and CX community.

Mission

A post-doctoral fellowship is available to work on the development of synchrotron serial crystallography (SSX) methods as applied to Metal Organic Framework (MOF) and PolyOxoMetalate (POM) micro-crystals. The objectives are to prepare slurries of samples, then collect, process and analyse SSX data from fixed targets and micro-fluidic devices that can be produced on site in SOLEIL’s dedicated micro-fluidics lab. The SSX experiments will be conducted on the beamline PROXIMA 2A with the general aim to determine transient crystal structures.

Further information is available from William SHEPARD (william.shepard@synchrotron-soleil.fr)

Qualification & Experience

The candidate should hold a Ph.D. in Physics, Chemistry or Structural Biology. They should have a solid background in crystallography and chemistry/biochemistry, as well as, in programming, conducting CX/MX experiments and crystallographic analysis. Previous experience in serial crystallography and/or microfluidics would be an advantage. A willingness to work on the beamline is essential.