Genomes of many organisms have been already sequenced and the number of proteins estimated to interact with a metal is high, more than 30% of the proteins for known genomes.
BioXAS (X-ray absorption spectroscopy applied to biological systems) can play an important role in metalloproteomics programmes as it gives information on the electronic structure of the metallic site and on the neighbouring atoms.
The first study weekend (held at LURE laboratory, on June 30-July 1, 2001) was dedicated to “Contribution of BioXAS to structural genomics: developments in theory & refinement methods”. The second study weekend (held at LURE laboratory, on June 29 - 30, 2003) was dedicated to ‘Genomics and BioXAS’.
These meetings, related in two special issues of the Journal of Synchrotron Radiation (2003, 10, and 2005, 12), confirmed that BioXAS can contribute to the structural genomics effort.
The 3rd BioXAS Study Weekend will be focused on “Metalloproteomics”
The purpose of SWE3 is to assemble the community interested in the characterization of protein metal sites. SWE3 will be a satellite meeting of the main international conference “Biology and Synchrotron Radiation 2007” (13-17 August—Manchester).
In the last ten years, BioXAS has been used as a powerful tool for local structural determination, on single crystals (in synergy with crystallography) and in solution, providing structural and electronic details during protein function.
Characterization of metal site both in steady state and during reaction concern metalloproteomic programmes.
Third generation synchrotron radiation sources (high flux and microfocused beam) extend the range of BioXAS experiments and provide new challenges on how to handle sample photosensitivity and build new experimental setups in which several techniques are combined.
Conference Chair
Please contact the hotel directly to reserve or cancel accommodation, with the mention “BIOXAS Study weekend”.