Pathological calcifications
Acknowledgments and publications

SOLEIL Company Contents / All the news / News 2013 / Pathological calcifications / Remerciements et publications
  • Introduction
  • Three families of pathological calcification
  • Epidemiology of lithiasis 
  • Some generalities on the physical chemistry of calculi 
  • Chemical diversity of mineral and organic phases 
  • Lithiasis, obesity and type 2 diabete
  • Randall’s plaques
  • Chemical composition of Randall’s plaque determined using X-ray absorption spectroscopy
  • Composition chimique de la plaque de Randall déterminée par Spectroscopie d’absorption X 
  • Ectopic calcifications present in renal biopsies 
  • Example of a clinical case diagnosed on the SMIS beamline at the SOLEIL synchrotron
  • Conclusion and perspectives
  • Acknowledgments and publications
  • Acknowledgments
    We thank Professor I. Brocheriou (Hôpital Tenon), Dr. X. Carpentier (Hôpital de Nice), Dr. Ch. Chappard (Hôpital Lariboisière), Prof. P. Conort (Groupe Hospitalier Pitié Salpétrière), Dr. P. Dorfmüller (Groupe Hospitalier Pitié Salpétrière), Prof. D. Hannouche (Hôpital Lariboisière), Prof. P. Jungers (Hôpital Necker), Prof. B. Knebelman (Hôpital Necker), Dr. E.A. Korn (Hôpital Lariboisière), Prof. F. Lioté (Hôpital Lariboisiere), Prof. M. Mathonnet (Hôpital de Limoges), Dr. P. Méria (Hôpital St Louis), Dr. Ch. Nguyen (Hôpital Lariboisière), Dr. J. Rode (Hôpital Tenon), Dr. I. Tostivint (Groupe Hospitalier Pitié Salpétrière), Prof. O. Traxer (Hôpital Tenon) et Prof. J.C. Williams (Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA) for providing samples and very exciting discussions.

    Also, regarding physicochemistry, this research could not have been performed without the scientific advice of Dr. P.-A. Albouy (LPS), Dr. G. André (LLB), Dr. A. Bianchi (INSERM-U7561), Dr. P. Chevallier (LURE), Dr. A. Cousson (LLB), Dr. P. Dumas (SOLEIL Synchrotron), Dr. B. Fayard (LPS), Dr. F. Fayon (CEHMTI), Dr. E. Foy (Laboratoire Pierre Süe), Dr. J. Frederick (SOLEIL Synchrotron), Dr. J. Guicheux (Laboratoire d’Ingénierie Ostéo-Articulaire et dentaire), Dr. J.L. Hazemann (ESRF), Dr. A. Lebail (Laboratoire des fluorures), Dr. F. Le Naour (Hôpital Paul Brousse), Dr. O. Mathon (ESRF), Dr. G. Matzen (CEHMTI), Dr. Ch. Mocuta (SOLEIL Synchrotron), Dr. P. Reboul, (UMR 7561), Dr. M. Refringiers (SOLEIL Synchrotron), Dr. S. Reguer (SOLEIL Synchrotron), Dr. S. Rouzière (LPS), Dr. J.P. Samama (SOLEIL Synchrotron), Dr. Ch. Sandt (SOLEIL Synchrotron), Dr. D. Thiaudière (SOLEIL Synchrotron), Dr. E. Véron (CEHMTI) and Dr. R. Weil (LPS).

    This work was supported by the Physic and Chemistry Institutes of CNRS, the Fondation pour la Recherche Médicale (grant DV020081013483 “Vieillissement ostéoarticulaire” 2008-2011, Pr Lioté), the Association Rhumatisme et Travail (ART), the Association “Cristaux et Cartilage” – PTD, the “Association pour la Recherche en Pathologie Synoviale, and by two ANR contracts, ANR-09-BLAN-0120-02 and ANR-12-BS08-0022-03.

    Authors’ publications:
    2008. Very first tests on SOLEIL regarding the Zn environment in pathological calcifications made of apatite determined by X-ray absorption spectroscopy.
    Bazin D, Carpentier X, Traxer O, Thiaudière D, Somogyi A, Reguer S, Waychunas G,Jungers P, Daudon M, J. Synchrotron Rad. 2008 ; 15 : 506.
    2009. Diffraction techniques and vibrational spectroscopy opportunities to characterise bones.
    D. Bazin, Ch. Chappard, C. Combes, X. Carpentier, S. Rouzière, G. André, G. Matzen, M. Allix, D. Thiaudière, S. Reguer, P. Jungers, M. Daudon, Osteop. Int. 20 (2009) 1065.
    2009. Revisiting the localisation of Zn2+ cations sorbed on pathological apatite calcifications made through X-ray absorption spectroscopy.
    D. Bazin, X. Carpentier, I. Brocheriou, P. Dorfmuller, S. Aubert, Ch. Chappard, D. Thiaudière, S. Reguer, G. Waychunas, P. Jungers and M. Daudon, Biochimie 91 (2009) 1294.
    2010. The pathogenesis of Randall’s Plaque : A papilla cartography of Ca compounds
    through an ex vivo investigation based on XANES spectroscopy.
    X.Carpentier, D. Bazin, P. Junger, S. Reguer, D. Thiaudière, M. Daudon, J. Syn. Rad. 17 (2010) 374.
    2011. Calcifications in human osteoarthritic articular cartilage : ex vivo assessment of calcium compounds using XANES spectroscopy.
    Nguyen C, Ea HK, Thiaudière D, Reguer S, Hannouche D, Daudon M, Lioté F, Bazin D., J Synchrotron Rad 2011 ; 18 :475-80.
    2011. Shedding Light on the chemical diversity of ectopic calcifications in kidney tissues: diagnostic and research aspects.
    Dessombz A, Bazin D, Dumas P, SandtCh, Sule-Suso J, Daudon M.. PlosOne 2011 ; 6 : e28007.
    2011. The status of Strontium in biological apatites : a XANES investigation.
    D. Bazin, M. Daudon, Ch. Chappard, J.J. Rehr, D. Thiaudière, S. Reguer, J. of Syn. Rad. 18 (2011) 912.
    2012. Characterization and some physicochemical aspects of pathological microcalcifications.
    Bazin D, Daudon M, Combes Ch, Rey Ch., Chem Rev 2012 ; 112 : 5092 – 120.
    2012. Pathological calcifications and selected examples at the medicine–solid-state physics interface.
    Bazin D, Daudon M, , J. Phys. D: Appl. Phys. 2012 ; 45 : 383001 - 383010.
    2012. Lithiase urinaire.
    Daudon M, Traxer O, Jungers P. 2d edition. Médecine-Sciences, Lavoisier, Paris