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PROXIMA 1 beamline

Research Contents / Beamlines / PROXIMA1

PROXIMA 1 is one of two beamlines at SOLEIL for measurements in macromolecular crystallography (together with PROXIMA 2, recently opened to users). PROXIMA 1, operational since March 2008, delivers an intense, parallel and tunable x-ray beam for measurements at high resolution or from large unit cell dimension crystals. The beamline has recently been upgraded with a very large surface area detector (PILATUS 6M). The 3 circle "kappa" geometry goniostat is in routine use for advanced data collection strategies. A new CATS sample changing robot has been installed on the beamline and is operational for cryogenically cooled samples. A crystallisation plate screening option will be available soon. The beamline optics implemented are such that they could permit a range of focussing conditions which can then be adapted to the sample being studied (for example beam focus at sample or detector).

 
A nano-crossbow in pathogenic bacteria ...
Crystal structure of part of the type VI secretion system solved on PROXIMA1
 
 

Among the multiple systems used by bacteria to survive and multiply, the T6SS- type VI secretion system is one of the main ones found in so-called Gram-negative bacteria, which include many species potentially pathogenic to humans (eg E. coli, P. aeruginosa). T6SS is a complex of more than 10 different proteins that enable these bacteria to target and inject toxins into their "prey" (prokaryotic or eukaryotic) cells after perforating their envelope. To accurately understand the molecular mechanisms that govern the secretory activity of this complex, researchers from the Pasteur Institute and the CNRS studied the structure of each of its elements, including experiments on PROXIMA1 and PROXIMA2. Their results were published in Nature. [Full story]


 
 
  More information | All the news
Description de la ligne Proxima 1

Thématiques scientifiques | Données techniques | L'équipe

Practical informations for users

Before the experiment | Troubleshooting | Users manual

Workshops

Workshop on Advanced Data Collection with Multi-Axis Goniometry

AtelierBioCrystallographie2016

 Beamline scientific articles

 Beamline PDB Entries

 News

- PROXIMA 1 and 2: Novel insights in the attachment of the bacterial carcinogen Helicobacter pylori

- Ribosome inhibitors: new structural basis unraveled in eukaryotes

- Noncoding RNA, the case of the LC ribozyme

- An intramolecular disulfide bridge regulates the affinity of human neuroglobin for oxygen

- Intensive industrial data collection using sample changer by VERNALIS, on PROXIMA 1: 110 data sets collected in 8:30. He says:

All the beamline news

 

 

 

 General information:

- Preliminary Project

- Beamline description 

Beamline poster

- PROXIMA2 Beamline

Download diagram of the energy ranges

 

 

How does the protein synthesis start in the cells?
The 3D structure of the e/aIF2 factor, a major actor of this stage, has been solved

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