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PROXIMA 1 beamline

Research Contents / Beamlines / PROXIMA1

PROXIMA 1 is one of two beamlines at SOLEIL for measurements in macromolecular crystallography (together with PROXIMA 2, recently opened to users). PROXIMA 1, operational since March 2008, delivers an intense, parallel and tunable x-ray beam for measurements at high resolution or from large unit cell dimension crystals. The beamline has recently been upgraded with a very large surface area detector (PILATUS 6M). The 3 circle "kappa" geometry goniostat is in routine use for advanced data collection strategies. A new CATS sample changing robot has been installed on the beamline and is operational for cryogenically cooled samples. A crystallisation plate screening option will be available soon. The beamline optics implemented are such that they could permit a range of focussing conditions which can then be adapted to the sample being studied (for example beam focus at sample or detector).

 
PROXIMA 1 - PROXIMA 2A
The crystallographic structure of the enzyme PolD suggests a new paradigm for classification of DNA polymerases
 
 

In all forms of cellular life, the enzymes DNA polymerases (DNAPs) play a central role in the replication, maintenance and repair of the genome. Consequently, the DNAPs have been the subject of intense research for many decades. Thanks to data collected using the PROXIMA-1 and PROXIMA-2A beamlines, teams at the Pasteur Institute and IFREMER have been able to resolve the structure of an archaeal DNAP. Their results show that while this enzyme is atypical amongst the different families of DNAPs, by contrast if shares some characteristics with RNA polymerases. The results are published in Nature Communications. [Full story]


 
 
  More information | All the news
Description de la ligne Proxima 1

Thématiques scientifiques | Données techniques | L'équipe

Practical informations for users

Before the experiment | Troubleshooting | Users manual

Workshops

Workshop on Advanced Data Collection with Multi-Axis Goniometry

AtelierBioCrystallographie2016

 Beamline scientific articles

 Beamline PDB Entries

 News

- Industrial anti-cancer research, assisted by diffraction data collected at SOLEIL, is reported in the journal Nature

- PROXIMA1 - PROXIMA2A: Regulation of gene expression - Take off your cap! 

- Structure of colloidal crystals

- The structure and the nutritive power of cockroach milk crystals

- A nano-crossbow in pathogenic bacteria ... Crystal structure of part of the type VI secretion system solved on PROXIMA1

All the beamline news

 

 

 

 General information:

- Preliminary Project

- Beamline description 

Beamline poster

- PROXIMA2 Beamline

Download diagram of the energy ranges

 

 

How does the protein synthesis start in the cells?
The 3D structure of the e/aIF2 factor, a major actor of this stage, has been solved

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