By comparison with other methods, the use of photons (X-rays, infrared etc.) is generally no or little destructive. In particular, most methods do not require the samples to be put under vacuum. It is also possible to work on bulk samples (without sampling, or prior preparation) in a great amount of cases. The sample environment (support, bulk) is generally very polyvalent.
Radiation damages occur however under certain conditions (mostly hard X-rays). In these sensitive cases, the beam can be focalized on a very small surface (about 1 micrometer per 1 micrometer) to limit the size of the affected areas (micro-destructive analysis).